Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome.

作者信息

Jekic Biljana, Novakovic Ivana, Lukovic Ljiljana, Kuzmanovic Milos, Popovic Branka, Milasin Jelena, Bunjevacki Gordana, Damnjanovic Tatjana, Cvjeticanin Suzana, Bunjevacki Vera

机构信息

Institute of Biology and Human Genetics, School of Medicine, 26 Visegradska Str., 11000 Belgrade, Serbia and Montenegro.

出版信息

Cancer Genet Cytogenet. 2006 Apr 15;166(2):163-5. doi: 10.1016/j.cancergencyto.2005.11.003.

DOI:10.1016/j.cancergencyto.2005.11.003

PMID:16631474

Abstract

Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults.

摘要