Wilensky Robert L, Song Hee Kwon, Ferrari Victor A
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C48-56. doi: 10.1016/j.jacc.2005.11.048.
Noninvasive magnetic resonance imaging (MRI) has been used to determine vascular three-dimensional structure, detect the presence of subclinical atherosclerotic disease in high-risk patient subgroups, and optimize and follow therapy in individual patients. The outstanding soft-tissue-characterizing capabilities of MRI permit depiction of various components of atherothrombotic plaque, including lipid, fibrous tissue, calcium, and thrombus formation. However, noninvasive MRI visualization of coronary arteries is currently limited by the small size of the coronary arteries, the deep arterial location, and arterial motion. The combination of MR imaging and molecular probes offers exciting possibilities of direct visualization of biologic processes within atherosclerotic tissue. The self-contained intravascular MRI probe appears to hold promise in the identification of high-risk coronary atherosclerotic lesions with increased superficial lipid content.
无创磁共振成像（MRI）已被用于确定血管三维结构、检测高危患者亚组中亚临床动脉粥样硬化疾病的存在，以及优化和跟踪个体患者的治疗。MRI出色的软组织特征显示能力可描绘动脉粥样硬化血栓形成斑块的各种成分，包括脂质、纤维组织、钙和血栓形成。然而，冠状动脉的无创MRI可视化目前受限于冠状动脉的小尺寸、动脉的深部位置以及动脉运动。MR成像与分子探针的结合为直接可视化动脉粥样硬化组织内的生物学过程提供了令人兴奋的可能性。独立的血管内MRI探针在识别具有增加的浅表脂质含量的高危冠状动脉粥样硬化病变方面似乎很有前景。
