Rasmusson Ida
Division of Clinical Immunology F79, Huddinge University Hospital, SE-141 86 Stockholm, Sweden.
Exp Cell Res. 2006 Jul 15;312(12):2169-79. doi: 10.1016/j.yexcr.2006.03.019. Epub 2006 Apr 24.
Mesenchymal stem cells (MSCs) have been shown to suppress activation of T cells both in vivo and in vitro. In vivo, this may be a way for the body to maintain homeostasis and inhibit immune activation in distinct compartments, such as the bone marrow and the interface between mother and fetus. MSCs modulate the immune function of the major cell populations involved in alloantigen recognition and elimination, including antigen presenting cells, T cells, and natural killer cells. The molecular mechanism that mediates the immunosuppressive effect of MSCs is not completely understood.
间充质干细胞（MSCs）已被证明在体内和体外均可抑制T细胞的激活。在体内，这可能是机体维持内环境稳定并抑制不同腔室（如骨髓以及母婴界面）免疫激活的一种方式。MSCs可调节参与同种异体抗原识别和清除的主要细胞群体的免疫功能，包括抗原呈递细胞、T细胞和自然杀伤细胞。介导MSCs免疫抑制作用的分子机制尚未完全明确。
