基于间充质干细胞的神经疾病细胞治疗：临床前和临床研究文献的简明综述。
MSC-Based Cell Therapy in Neurological Diseases: A Concise Review of the Literature in Pre-Clinical and Clinical Research.
机构信息
University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province/Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
出版信息
Biomolecules. 2024 Apr 30;14(5):538. doi: 10.3390/biom14050538.
Abstract
Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to self-renew and multi-directional differentiation potential. Exogenously administered MSCs can migrate to damaged tissue sites and participate in the repair of damaged tissues. A large number of pre-clinical studies and clinical trials have demonstrated that MSCs have the potential to treat the abnormalities of congenital nervous system and neurodegenerative diseases. Therefore, MSCs hold great promise in the treatment of neurological diseases. Here, we summarize and highlight current progress in the understanding of the underlying mechanisms and strategies of MSC application in neurological diseases.
摘要
间充质干细胞（MSCs）是具有自我更新和多向分化潜能的多能基质细胞。外源性给予的 MSCs 可以迁移到受损组织部位，并参与受损组织的修复。大量的临床前研究和临床试验表明，MSCs 具有治疗先天性神经系统异常和神经退行性疾病的潜力。因此，MSCs 在治疗神经疾病方面具有广阔的前景。在这里，我们总结并强调了目前对 MSCs 在神经疾病中应用的潜在机制和策略的理解的最新进展。
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