突变型和野生型亨廷顿蛋白片段的反常聚集与寡聚化特性 - Suppr

Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments.

作者信息

Rubinsztein David C, Huntington James A

机构信息

Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK.

出版信息

Exp Neurol. 2006 Jun;199(2):243-4. doi: 10.1016/j.expneurol.2006.03.006. Epub 2006 Apr 24.

DOI:10.1016/j.expneurol.2006.03.006

PMID:16631742

Abstract

摘要

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Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments.

Exp Neurol. 2006 Jun;199(2):243-4. doi: 10.1016/j.expneurol.2006.03.006. Epub 2006 Apr 24.

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Huntingtin contains a highly conserved nuclear export signal.

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14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein.

Neurosci Lett. 2008 Jan 24;431(1):45-50. doi: 10.1016/j.neulet.2007.11.018. Epub 2007 Nov 17.

Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases.

Arch Neurol. 2010 Apr;67(4):388-92. doi: 10.1001/archneurol.2010.40.

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Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments.

Exp Neurol. 2006 Jun;199(2):243-4. doi: 10.1016/j.expneurol.2006.03.006. Epub 2006 Apr 24.

Nucleation of huntingtin aggregation in cells.

Nat Chem Biol. 2006 Jun;2(6):297-8. doi: 10.1038/nchembio0606-297.

Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro.

J Biol Chem. 2009 May 1;284(18):11845-53. doi: 10.1074/jbc.M900639200. Epub 2009 Mar 6.

Toward cell specificity in SCA1.

Neuron. 2002 May 30;34(5):669-70. doi: 10.1016/s0896-6273(02)00715-8.

Interacting proteins as genetic modifiers of Huntington disease.

Trends Genet. 2007 Nov;23(11):531-3. doi: 10.1016/j.tig.2007.07.007. Epub 2007 Oct 24.

Neurodegenerative disease: neuron protection agency.

Nature. 2004 Oct 14;431(7010):747-8. doi: 10.1038/431747a.

Reversing neurodegeneration: a promise unfolds.

Cell. 2000 Mar 31;101(1):1-4. doi: 10.1016/S0092-8674(00)80617-0.

Huntingtin contains a highly conserved nuclear export signal.

Hum Mol Genet. 2003 Jun 15;12(12):1393-403. doi: 10.1093/hmg/ddg156.

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein.

Neurosci Lett. 2008 Jan 24;431(1):45-50. doi: 10.1016/j.neulet.2007.11.018. Epub 2007 Nov 17.

Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases.

Arch Neurol. 2010 Apr;67(4):388-92. doi: 10.1001/archneurol.2010.40.

引用本文的文献

Autophagy is increased in postmortem brains of persons with HIV-1-associated encephalitis.

J Infect Dis. 2011 Jun 1;203(11):1647-57. doi: 10.1093/infdis/jir163.

Formation and toxicity of soluble polyglutamine oligomers in living cells.

PLoS One. 2010 Dec 28;5(12):e15245. doi: 10.1371/journal.pone.0015245.

Autophagy: an overlooked mechanism of HIV-1 pathogenesis and neuroAIDS?

Autophagy. 2008 Jul;4(5):704-6. doi: 10.4161/auto.6105. Epub 2008 Apr 14.

Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments.

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Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments.

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