Pollak Edward
Department of Statistics, Iowa State University, Ames, IA 50011, USA.
Math Biosci. 2006 Jul;202(1):133-55. doi: 10.1016/j.mbs.2006.03.009. Epub 2006 Apr 24.
Consider a random mating population that has N(m) males and N(f) females in each generation. Let us assume that at time 0 a random sample of n copies of a gene is taken from this population. Then, for models introduced by Wright [Evolution in Mendelian populations, Genetics 16 (1931) 97; Inbreeding and homozygosis, Proc. Nat. Acad. Wash. 19 (1933) 420; Evolution and the Genetics of Populations, The Theory of Gene Frequencies, vol. II, The University of Chicago, Chicago and London, 1969.], it is possible to obtain generalizations of the haploid theory of genealogical processes developed by Felsenstein . It is conjectured that these hold generally, regardless of the effective population size, if n<<min(N(m),N(f)). Generalizations are also proved to hold if n=2.
考虑一个随机交配群体,每一代中有N(m)个雄性和N(f)个雌性。假设在时间0时,从该群体中随机抽取n个基因拷贝作为样本。那么,对于赖特[《孟德尔群体中的进化》,《遗传学》16 (1931) 97;《近亲繁殖与纯合性》,《美国国家科学院院刊》19 (1933) 420;《进化与群体遗传学,基因频率理论》,第二卷,芝加哥大学,芝加哥和伦敦,1969年]所引入的模型,有可能得到费尔森斯坦所发展的谱系过程单倍体理论的推广。据推测,如果n << min(N(m), N(f)),这些推广普遍成立,与有效群体大小无关。如果n = 2,也证明了这些推广是成立的。