Pol-Rodriguez Marlyanne M, Fox Lindy P, Sulis Maria Luisa, Miller Ira J, Garzon Maria C
Department of Dermatology, Columbia University Medical Center, New York, NY, USA.
J Am Acad Dermatol. 2006 May;54(5 Suppl):S192-7. doi: 10.1016/j.jaad.2005.07.022.
Natural killer (NK)-cell neoplasms are relatively uncommon tumors. Classification schemes prior to that of the World Health Organization (2001) did not account clearly for these neoplasms. Advances in immunohematology over the past 10 years have aided in the recognition and categorization of NK-cell tumors. One type of tumor that belongs to this class is extranodal, nasal-type NK/T-cell lymphoma. These lymphoma cells express a cytotoxic T-cell or NK-cell phenotype, including CD56 and TIA-1. Nasal-type NK/T-cell lymphomas arise from extranasal sites such as the skin and are often associated with Epstein-Barr virus infection. Asian adults are affected most commonly. Very few pediatric cases are reported in the literature, of which only 5 presented with cutaneous involvement. We report a case of an adolescent Bangladeshi boy with extranodal, nasal-type NK/T-cell lymphoma who had cutaneous nodules on the extremities.
自然杀伤（NK）细胞肿瘤是相对罕见的肿瘤。在世界卫生组织（2001年）的分类方案之前，这些肿瘤没有得到明确的分类。过去10年免疫血液学的进展有助于识别和分类NK细胞肿瘤。属于此类的一种肿瘤是结外鼻型NK/T细胞淋巴瘤。这些淋巴瘤细胞表达细胞毒性T细胞或NK细胞表型，包括CD56和TIA-1。鼻型NK/T细胞淋巴瘤起源于鼻外部位，如皮肤，并且常与爱泼斯坦-巴尔病毒感染相关。亚洲成年人最常受影响。文献中报道的儿科病例很少，其中只有5例有皮肤受累。我们报告一例患有结外鼻型NK/T细胞淋巴瘤的孟加拉国青少年男孩，其四肢有皮肤结节。
