Grimes Pearl, Nordlund James J, Pandya Amit G, Taylor Susan, Rendon Marta, Ortonne Jean-Paul
Vitiligo & Pigmentation Institute of Southern California, Division of Dermatology, University of California, Los Angeles, CA, USA.
J Am Acad Dermatol. 2006 May;54(5 Suppl 2):S255-61. doi: 10.1016/j.jaad.2005.12.042.
This article focuses on developments in pigmentary disorders that extend dermatologists' understanding of the field. Areas that are reviewed include the basic biochemistry, pharmacology, and physiology of the melanocortin system; melanosome development; genetic diseases associated with pigmentary disorders; pigmentary disorders secondary to systemic disease; drug-induced hyperpigmentation; environmental exposure to chemicals; and primary disorders of hyperpigmentation such as melasma and lentigines. Basic, clinical, and epidemiological research, along with a number of clinical case reports, were included in the review. This article also reports on the new health-related quality-of-life instrument (MELASQOL) that has been developed for women with melasma.
本文聚焦于色素性疾病的进展，这些进展拓展了皮肤科医生对该领域的认识。所综述的领域包括黑素皮质素系统的基础生物化学、药理学和生理学；黑素小体的发育；与色素性疾病相关的遗传疾病；全身性疾病继发的色素性疾病；药物性色素沉着；环境化学物质暴露；以及色素沉着过度的原发性疾病，如黄褐斑和雀斑。综述纳入了基础、临床和流行病学研究，以及一些临床病例报告。本文还报告了一种专为黄褐斑女性开发的新的健康相关生活质量工具（MELASQOL）。
