Hadi Doaa Falih, El-Taweel Abdel-Aziz Ibrahim, Mustafa Amany Ibrahim, El-Shimi Ola Samir, Rageh Mahmoud A
Department of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
Ir J Med Sci. 2025 May 30. doi: 10.1007/s11845-025-03966-9.
Vitiligo is a cutaneous disease caused by the destruction of functioning melanocytes. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity.
We tried to investigate the association between MIF (rs755622) gene polymorphism and vitiligo susceptibility and its relationship to severity and clinical types of the disease.
Fifty patients with vitiligo and 50 healthy controls were included. Determination of MIF gene (rs755622) single nucleotide polymorphism was conducted using polymerase chain reaction (PCR).
There were 18 males and 32 females who had vitiligo, together with 50 control participants of matched age and gender. Taking GG genotype and G allele as references, MIF GC, CC, (GC + CC) genotypes, and C allele demonstrated a substantially higher occurrence in all patients when compared to controls, with a higher risk of developing vitiligo within healthy control subjects.
To the best of our knowledge, this is the third study worldwide and the first from Egypt to investigate the association between MIF gene polymorphism (rs755622) with vitiligo susceptibility and severity, and it showed that MIF gene polymorphism (rs755622) may be considered a risk factor for vitiligo susceptibility. Moreover, it may be associated with higher disease extent.
白癜风是一种由功能性黑素细胞破坏引起的皮肤病。已知细胞免疫在白癜风的发病机制中起作用。巨噬细胞移动抑制因子（MIF）是巨噬细胞的一种有效激活剂，被认为在细胞介导的免疫中起重要作用。
我们试图研究MIF（rs755622）基因多态性与白癜风易感性之间的关联及其与疾病严重程度和临床类型的关系。
纳入50例白癜风患者和50例健康对照。采用聚合酶链反应（PCR）测定MIF基因（rs755622）单核苷酸多态性。
白癜风患者中男性18例，女性32例，另有50名年龄和性别匹配的对照参与者。以GG基因型和G等位基因为参照，与对照组相比，MIF的GC、CC、（GC + CC）基因型以及C等位基因在所有患者中的出现率显著更高，在健康对照受试者中患白癜风的风险更高。
据我们所知，这是全球第三项研究，也是埃及第一项研究MIF基因多态性（rs755622）与白癜风易感性及严重程度之间关联的研究，结果表明MIF基因多态性（rs755622）可能被视为白癜风易感性的一个风险因素。此外，它可能与更高的疾病范围相关。
