Simon Peter, Spilcke-Liss Elisabeth, Wallaschofski Henri
Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt-University, Friedrich Loeffler Strasse 23A, D-17487 Greifswald, Germany.
Endocrinol Metab Clin North Am. 2006 Jun;35(2):431-47, xii. doi: 10.1016/j.ecl.2006.02.011.
Neuroendocrine tumors of the pancreas are rare neoplasms of the heterogeneous group of neuroendocrine gastroenteropancreatic tumors that originate from totipotential stem cells or preexisting endocrine cells within the pancreas. Most neuroendocrine tumors of the pancreas are benign or show an indolent course of disease.A subset of them shows a very aggressive behavior, becomes highly malignant, and metastasizes early with life-limiting consequences. An effective disease-management includes the diagnostic approach with hormonal testing and localization and surgical treatment with histologic classification in combination with biotherapy, chemotherapy, or therapy with radionucleotides, de-pending on the individual behavior of the tumor. The primary goal is the improvement of symptoms leading to an acceptable quality of life in the individual patient.
胰腺神经内分泌肿瘤是神经内分泌胃肠胰腺肿瘤这一异质性肿瘤组中的罕见肿瘤，起源于胰腺内的全能干细胞或已有的内分泌细胞。大多数胰腺神经内分泌肿瘤是良性的，或呈现疾病进展缓慢的病程。其中一部分表现出极具侵袭性的行为，会发展为高度恶性，并早期发生转移，产生危及生命的后果。有效的疾病管理包括通过激素检测和定位进行诊断，以及结合生物疗法、化疗或放射性核素治疗进行组织学分类的手术治疗，具体取决于肿瘤的个体行为。主要目标是改善症状，使个体患者获得可接受的生活质量。
