Wee Hwee-Lin, Li Shu-Chuen, Cheung Yin-Bun, Fong Kok-Yong, Thumboo Julian
Department of Pharmacy, National University of Singapore, and Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Republic of Singapore.
J Diabetes Complications. 2006 May-Jun;20(3):170-8. doi: 10.1016/j.jdiacomp.2005.06.010.
The aims of this study were to evaluate the influence of ethnicity on health-related quality of life (HRQoL) in diabetic participants using both profile [the Short-Form 36 (SF-36)] and single-index (the SF-6D) instruments and to evaluate the usefulness of the SF-6D as a summary measure for the SF-36.
Using data from a cross-sectional, population-based survey of Chinese, Malay, and Indians in Singapore, we analyzed the influence of ethnicity and other variables on each SF-36 scale and SF-6D scores using linear regression models to adjust for the influence of known determinants of HRQoL.
Data from 309 diabetic respondents were analyzed. Compared with other ethnicities, Indians were most likely to report impaired HRQoL. The unadjusted influence of ethnicity on HRQoL exceeded the minimum clinically important difference (MCID) for all SF-36 scales (MCID: 5 points) and the SF-6D (MCID: 0.033 points). After adjusting for gender, age, and education, the influence of Chinese ethnicity exceeded the MCID for all SF-36 scales, except vitality (VT) and mental health (MH), as well as for the SF-6D. The influence of Malay ethnicity exceeded the MCID only for the SF-36 MH scale and the SF-6D. The influence of ethnicity on HRQoL persisted after adjusting further for other determinants of HRQoL. The SF-6D reflected the ethnic trends for some but not all SF-36 scales.
After adjusting for demographic, socioeconomic, and other factors known to influence HRQoL, ethnicity remained an important factor influencing HRQoL in this population-based multiethnic sample of diabetic Asians. Further studies to identify modifiable factors explaining the ethnic disparities in HRQoL among diabetic participants are needed. The SF-6D may be a useful summary measure for the SF-36.
本研究旨在使用概况量表（简短健康调查问卷36项简表，即SF - 36）和单一指标量表（SF - 6D）评估种族对糖尿病患者健康相关生活质量（HRQoL）的影响，并评估SF - 6D作为SF - 36总结性指标的实用性。
利用新加坡一项基于人群的横断面调查中有关华人、马来人和印度人的数据，我们使用线性回归模型分析种族及其他变量对各SF - 36量表和SF - 6D得分的影响，以校正已知的HRQoL决定因素的影响。
分析了309名糖尿病受访者的数据。与其他种族相比，印度人报告HRQoL受损的可能性最大。种族对HRQoL的未校正影响超过了所有SF - 36量表（最小临床重要差异[MCID]：5分）和SF - 6D（MCID：0.033分）的最小临床重要差异。在调整性别、年龄和教育程度后，华人种族的影响在除活力（VT）和心理健康（MH）外的所有SF - 36量表以及SF - 6D方面均超过了MCID。马来种族的影响仅在SF - 36的MH量表和SF - 6D方面超过了MCID。在进一步校正其他HRQoL决定因素后，种族对HRQoL的影响依然存在。SF - 6D反映了部分而非全部SF - 36量表的种族趋势。
在校正了已知影响HRQoL的人口统计学、社会经济和其他因素后，在这个基于人群的多民族亚洲糖尿病样本中，种族仍然是影响HRQoL的一个重要因素。需要进一步开展研究以确定可解释糖尿病患者HRQoL种族差异的可改变因素。SF - 6D可能是SF - 36的一个有用的总结性指标。
