Lebel M H
Département de pédiatrie et département de microbiologie et immunologie, hôpital Sainte-Justine, Montréal, Québec, Canada.
Pediatrie. 1991;46(5):417-27.
Recent developments in the pathogenesis, epidemiology and therapy of bacterial meningitis are presented. The importance of interleukin-1 beta, tumor necrosis factor alpha, and prostaglandins as generators of inflammation within the central nervous system in animals and children is described. The role of mediators of inflammation such as dexamethasone in the experimental meningitis model and in clinical studies is reviewed. The optimal duration of therapy and the role of cephalosporins in bacterial meningitis are discussed.
本文介绍了细菌性脑膜炎发病机制、流行病学和治疗方面的最新进展。描述了白细胞介素-1β、肿瘤坏死因子α和前列腺素在动物和儿童中枢神经系统炎症发生中的重要性。综述了地塞米松等炎症介质在实验性脑膜炎模型和临床研究中的作用。讨论了细菌性脑膜炎的最佳治疗持续时间以及头孢菌素的作用。
