Beattie R M, Croft N M, Fell J M, Afzal N A, Heuschkel R B
Paediatric Medical Unit, Southampton General Hospital, Southampton, UK.
Arch Dis Child. 2006 May;91(5):426-32. doi: 10.1136/adc.2005.080481.
Twenty five per cent of inflammatory bowel disease presents in childhood. Growth and nutrition are key issues in the management with the aim of treatment being to induce and then maintain disease remission with minimal side effects. Only 25% of Crohn's disease presents with the classic triad of abdominal pain, weight loss, and diarrhoea. Most children with ulcerative colitis have blood in the stool at presentation. Inflammatory markers are usually although not invariably raised at presentation (particularly in Crohn's disease). Full investigation includes upper gastrointestinal endoscopy and ileocolonoscopy. Treatment requires multidisciplinary input as part of a clinical network led by a paediatrician with special expertise in the management of the condition.
25%的炎症性肠病在儿童期发病。生长和营养是治疗中的关键问题，治疗目标是诱导并维持疾病缓解，同时使副作用最小化。只有25%的克罗恩病表现为腹痛、体重减轻和腹泻的典型三联征。大多数溃疡性结肠炎患儿在发病时大便带血。炎症标志物在发病时通常（但并非总是）升高（尤其是在克罗恩病中）。全面检查包括上消化道内镜检查和回结肠镜检查。治疗需要多学科参与，作为由在该疾病管理方面具有特殊专业知识的儿科医生领导的临床网络的一部分。
