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肺叶肺不张的选择性募集策略:对肺功能和中心血流动力学的影响:一项在猪身上的实验研究

Selective recruitment maneuvers for lobar atelectasis: effects on lung function and central hemodynamics: an experimental study in pigs.

作者信息

Hansen Lars Kjaersgaard, Sloth Erik, Nielsen Jonas, Koefoed-Nielsen Jacob, Lambert Per, Lunde Søren, Larsson Anders

机构信息

Department of Anesthesia and Intensive Care Medicine, Center for Cardiovascular Research, Aalborg Hospital, Aalborg, Denmark.

出版信息

Anesth Analg. 2006 May;102(5):1504-10. doi: 10.1213/01.ane.0000202477.29064.49.

Abstract

We investigated whether selective lung recruitment of a lobar collapse would improve oxygenation and lung volume as well as a general (global) lung recruitment maneuver, with fewer circulatory side effects. In 10 ventilated, anesthetized pigs, a bronchial blocker was inserted in the right lower lobe, which was selectively lavaged to create a dense lobar collapse. The pigs were randomized into two orders of lung recruitment maneuvers (40 cm H2O airway pressure for 30 s): either a selective lung recruitment maneuver (using the inner lumen of the bronchial blocker) followed by a general lung recruitment maneuver, or vice versa. Median end-expiratory lung volume and median Pao2 increased significantly by approximately 100 mL and 16 kPa, respectively, with no significant differences between the two recruitment methods. There were no circulatory changes during the selective lung recruitment maneuver, but during the general lung recruitment maneuver, mean arterial blood pressure decreased significantly by 36 (21, 41) mm Hg (median, 25th and 75th percentiles), cardiac output by 2.1 (1.6, 2.5) L/min and left ventricular end-diastolic area by 4.4 (3.5, 4.5) cm2. In conclusion, a selective recruitment maneuver improved lung function similar to a general lung recruitment maneuver but without any circulatory side effects.

摘要

我们研究了对肺叶萎陷进行选择性肺复张是否能改善氧合和肺容积,以及是否能像常规(全肺)肺复张操作那样改善肺功能,同时减少循环系统副作用。在10只接受机械通气、麻醉的猪中,将支气管封堵器插入右下叶,对该叶进行选择性灌洗以造成严重的肺叶萎陷。将这些猪随机分为两种肺复张操作顺序(气道压力40 cm H2O,持续30秒):要么先进行选择性肺复张操作(通过支气管封堵器的内腔),然后进行常规肺复张操作,要么顺序相反。呼气末肺容积中位数和动脉血氧分压中位数分别显著增加约100 mL和16 kPa,两种复张方法之间无显著差异。在选择性肺复张操作过程中没有循环系统变化,但在常规肺复张操作过程中,平均动脉血压显著下降36(21,41)mmHg(中位数、第25和第75百分位数),心输出量下降2.1(1.6,2.5)L/min,左心室舒张末期面积下降4.4(3.5,4.5)cm²。总之,选择性复张操作改善肺功能的效果与常规肺复张操作相似,但没有任何循环系统副作用。

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