Magone M Teresa, Maric Irina, Hwang David G
Cornea Service, Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143-0730, USA.
Cornea. 2006 Apr;25(3):364-7. doi: 10.1097/01.ico.0000176604.95000.f3.
To report a case of peripheral interstitial keratitis in a patient with mastocytosis.
Clinical case description and immunohistologic examination of biopsied ocular tissue.
A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial keratitis with vascularization associated with foreign body sensation and itching. Biomicroscopy of the cornea showed deep corneal inflammatory infiltrates and midstromal vascularization adjacent to a region of superior bulbar conjunctiva, which was mildly chemotic and inflamed. Topical mast cell stabilizers and a short course of topical steroids produced dramatic resolution of the lesion. Biopsy of the erythematous conjunctiva adjacent to the area of corneal inflammation showed the presence of mast cells.
This is the first case of corneal inflammatory infiltration in a patient with mastocytosis. Therapy for this condition consists of a combination of topical mast cell stabilizers, topical steroids, and systemic antihistaminic therapy.
报告1例肥大细胞增多症患者发生周边性间质性角膜炎的病例。
对活检的眼部组织进行临床病例描述及免疫组织学检查。
一名22岁女性，经活检证实为色素性荨麻疹（肥大细胞增多症的一个亚型），表现为伴有血管化的活动性周边性间质性角膜炎，伴有异物感和瘙痒。角膜生物显微镜检查显示角膜深层炎性浸润及与上方球结膜区域相邻的基质中层血管化，该区域球结膜轻度水肿且发炎。局部应用肥大细胞稳定剂及短期局部应用类固醇使病变显著消退。对角膜炎症区域相邻的红斑性结膜进行活检显示存在肥大细胞。
这是肥大细胞增多症患者发生角膜炎性浸润的首例病例。该病症的治疗包括局部应用肥大细胞稳定剂、局部应用类固醇及全身抗组胺治疗。
