Choi Hyuk Jin, Kim Dong Myung, Hwang Seung-Sik
Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
J Glaucoma. 2006 Apr;15(2):120-3. doi: 10.1097/00061198-200604000-00008.
To determine whether central corneal thickness (CCT) is related to the extent of localized retinal nerve fiber layer (RNFL) defect at the initial examination of normal-tension glaucoma (NTG) patients.
Seventy-five eyes of 75 NTG patients showing localized RNFL defects on RNFL photographs and corresponding visual field defects at the initial visit to a glaucoma specialist were selected for this study. All participants completed refraction, Goldmann applanation tonometry, CCT measurement, stereoscopic disc photography, RNFL photography, and automated perimetry. Each patient's age, spherical equivalent, intraocular pressure, CCT, approximation of the RNFL defect to the fovea (angle alpha), circumferential width of the RNFL defects (angle beta), horizontal and vertical cup-to-disc ratios, and mean deviation of visual field were analyzed.
In univariate and multivariate analyses, lower CCT was significantly associated with increased horizontal and vertical cup-to-disc ratios, decreased angle alpha, and increased angle beta. For a decrease of 10 microm of CCT, horizontal and vertical cup-to-disc ratios increased by 0.020, angle alpha decreased by 1.58 degrees, and angle beta increased by 1.71 degrees, respectively.
CCT is a significant factor in predicting the extent of localized RNFL defect at the initial examination of NTG patients.
确定在正常眼压性青光眼（NTG）患者初诊时，中央角膜厚度（CCT）是否与局限性视网膜神经纤维层（RNFL）缺损的范围相关。
本研究选取了75例NTG患者的75只眼，这些患者在初次就诊于青光眼专科医生时，RNFL照片显示有局限性RNFL缺损且伴有相应的视野缺损。所有参与者均完成了验光、Goldmann压平眼压测量、CCT测量、立体视盘照相、RNFL照相及自动视野检查。分析了每位患者的年龄、等效球镜度、眼压、CCT、RNFL缺损与黄斑中心凹的接近程度（α角）、RNFL缺损的圆周宽度（β角）、水平和垂直杯盘比以及视野平均偏差。
在单因素和多因素分析中，较低的CCT与水平和垂直杯盘比增加、α角减小及β角增大显著相关。CCT每降低10微米，水平和垂直杯盘比分别增加0.020，α角减小1.58度，β角增加1.71度。
在NTG患者初诊时，CCT是预测局限性RNFL缺损范围的一个重要因素。
