Shang Yongfeng
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China.
Nat Rev Cancer. 2006 May;6(5):360-8. doi: 10.1038/nrc1879.
Endometrial cancer is the most common gynaecological cancer, and is associated with endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast cancer using selective oestrogen-receptor modulators (SERMs), particularly tamoxifen. Oestrogen and SERMs are thought to be involved in endometrial carcinogenesis through their effects on transcriptional regulation. Ultimately, oestrogen and SERMs affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2 (paired box 2).
子宫内膜癌是最常见的妇科癌症，与子宫内膜增生、无对抗性雌激素暴露以及使用选择性雌激素受体调节剂（SERM）进行的乳腺癌辅助治疗有关，尤其是他莫昔芬。雌激素和SERM被认为通过其对转录调控的影响参与子宫内膜癌发生。最终，雌激素和SERM通过下游效应因子如PAX2（配对盒基因2）影响控制细胞生长和增殖的细胞信号通路的转导。
