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Production of the thiyl free radical by the reaction of N-methyl-N'-nitro-N-nitrosoguanidine with L-cysteine.

作者信息

Mikuni T, Tatsuta M

机构信息

Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.

出版信息

Biochem Int. 1991 Jun;24(3):585-91.

PMID:1663347
Abstract

The thiyl free radical is formed in the L-cysteine/N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) system (pH 7.8) without exposure to light as detected by the ESR spin trapping technique. The formation of N-methyl-N'-nitroguanidine in the system is identified by thin-layer chromatography. The hypothesis that the thiyl radical is formed by the attack of the nucleophilic reagent L-cysteine on the nitroso group of MNNG is verified by these results.

摘要

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