Dolan Fiona M, Sandinha Teresa, Purdy Alistair, Parks Stuart, Keating David
Ophthalmology Department, Tennent Institute of Ophthalmology, Gartnavel General Hospital, Great Western Road, Glasgow, G12 0YN, UK.
Doc Ophthalmol. 2006 Jan;112(1):31-4. doi: 10.1007/s10633-006-0002-1.
We report an observational case study which showed that the rod pathway may have a significant effect on the multifocal electroretinogram (mfERG). A 68-year-old lady diagnosed with Vitamin A deficiency underwent standard ERG and mfERG. ERG rod and cone function were analysed and the first order mfERG responses were determined. At presentation, there was no demonstrable rod function on ERG testing and normal cone function. mfERG P1 amplitude responses were normal but mfERG P1 latency responses were significantly delayed. Four weeks after initiating treatment with intramuscular Vitamin A, ERG rod function significantly improved. However, cone amplitude was reduced and the 30 Hz flicker latencies decreased. Furthermore, mfERG P1 latency returned to normal and interestingly mfERG P1 amplitude responses showed a significant reduction. These results alter our understanding of the mfERG response by indicating that there is a possible inhibitory influence on mfERG responses from rod pathway systems.
我们报告了一项观察性病例研究，该研究表明视杆细胞通路可能对多焦视网膜电图（mfERG）有显著影响。一名被诊断为维生素A缺乏症的68岁女性接受了标准视网膜电图（ERG）和多焦视网膜电图检查。分析了ERG视杆和视锥细胞功能，并确定了一级mfERG反应。初诊时，ERG检查显示视杆细胞功能未得到证实，视锥细胞功能正常。mfERG的P1波幅反应正常，但mfERG的P1波潜伏期反应明显延迟。在开始肌肉注射维生素A治疗四周后，ERG视杆细胞功能显著改善。然而，视锥细胞波幅降低，30Hz闪烁潜伏期缩短。此外，mfERG的P1潜伏期恢复正常，有趣的是，mfERG的P1波幅反应显著降低。这些结果改变了我们对mfERG反应的理解，表明视杆细胞通路系统可能对mfERG反应有抑制作用。
