Wade C E, Hannon J P
Letterman Army Institute of Research, Division of Military Trauma Research, Presidio of San Francisco, CA 94129-6800.
Circ Shock. 1991 Aug;34(4):379-84.
Responses of the pituitary-adrenal axis to hemorrhagic hypotension were compared in chronically instrumented swine that were allowed to move freely in a holding cage (n = 11) and swine trained to accept physical restraint in a Pavlov sling (n = 14). Seven to ten days after surgical preparation, each animal was hemorrhaged (37.5 ml/kg over 60 min) while confined to its environment. Before hemorrhage, control values for ACTH, cortisol, heart rate, and mean arterial pressure were at near-basal levels in both groups, and during hemorrhage both groups showed similar decrements in blood pressure. Hemorrhage in the sling animals, however, led to increases in plasma ACTH and cortisol concentration much greater than those seen in caged animals. Log-linear plots of ACTH against mean arterial pressure revealed similar response characteristics in the two groups but significant rightward shift of the response curve in sling-restrained animals. Our results indicate that sling restraint, even in highly trained animals, potentiates pituitary-adrenal responses to hemorrhage by some as yet unknown mechanism.
在长期植入仪器的猪中，比较了垂体 - 肾上腺轴对出血性低血压的反应。这些猪被分为两组，一组在饲养笼中自由活动（n = 11），另一组在巴甫洛夫吊带中接受物理约束训练（n = 14）。手术准备7至10天后，每只动物在其所处环境中被放血（60分钟内放血37.5 ml/kg）。放血前，两组动物的促肾上腺皮质激素（ACTH）、皮质醇、心率和平均动脉压的对照值均接近基础水平，放血期间两组动物的血压均出现类似下降。然而，吊带组动物放血后血浆ACTH和皮质醇浓度的升高幅度远大于笼养组动物。ACTH与平均动脉压的对数线性图显示两组具有相似的反应特征，但吊带约束组动物的反应曲线明显右移。我们的结果表明，即使是在训练有素的动物中，吊带约束也会通过某种尚不清楚的机制增强垂体 - 肾上腺对出血的反应。
