Bridgers S L
CNS Medical Research Miles Inc., Pharmaceutical Division, West Haven, CT.
Electroencephalogr Clin Neurophysiol Suppl. 1991;43:170-9.
The potential of transcranial magnetic stimulation (TMS) to cause undesired or unexpected effects on cognition and other cerebral functions has received only limited study, although extensive clinical use has suggested that obvious problems are unlikely. Evidence so far accumulated suggests that exposure to TMS in the expected clinical situations will have no persistent effects on the electroencephalogram (EEG) or on cognitive function, although transient effects may occur. The absence of increases in either prolactin or adrenocorticotropic hormone (ACTH) in subjects undergoing TMS indicates that seizure-like events do not routinely occur, although recent evidence suggests that TMS may cause seizures or enhance the occurrence of epileptiform abnormalities in circumstances of heightened susceptibility. Despite these observations, treated seizure patients are unlikely to experience seizures with TMS. The technique is generally safe, but not entirely free from unwanted effects, and further study to define those effects is warranted.
尽管经颅磁刺激（TMS）已广泛应用于临床，但关于其对认知及其他脑功能产生不良或意外影响的潜在可能性，相关研究仍较为有限，不过目前的广泛临床应用表明出现明显问题的可能性不大。目前积累的证据显示，在预期的临床情况下接受TMS治疗，对脑电图（EEG）或认知功能不会产生持续性影响，尽管可能会出现短暂性影响。接受TMS治疗的受试者中催乳素或促肾上腺皮质激素（ACTH）均未升高，这表明癫痫样发作通常不会发生，不过最近有证据表明，在易感性增强的情况下，TMS可能会引发癫痫或增加癫痫样异常的发生几率。尽管如此，接受治疗的癫痫患者在接受TMS治疗时不太可能出现癫痫发作。该技术总体上是安全的，但并非完全没有不良影响，因此有必要进一步研究以明确这些影响。
