Rogan Eleanor G
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.
In Vivo. 2006 Mar-Apr;20(2):221-8.
The hydrolysis product of glucobrassicin, indole-3-carbinol (I3C), is metabolized to a variety of products, including the dimeric 3,3'-diindolylmethane (DIM). Both I3C and DIM exert a variety of biological and biochemical effects. Most of these effects appear to occur because I3C modulates several nuclear transcription factors. I3C induces phase I and phase II enzymes that metabolize carcinogens, including estrogens. Administration of either I3C or DIM results in increased 2-hydroxylation of estrogens. I3C also enhances DNA repair by affecting several of the proteins involved in this process. I3C induces both G1 cell cycle arrest and apoptosis. All of these activities lead to anticancer effects. Although I3C has been shown to protect against tumor induction by some carcinogens, it has also been observed to promote tumor development in animal models. In humans, I3C and DIM affect the metabolism of estrogens. Concerns have been raised that I3C might increase the formation of estrogen metabolites that induce or promote cancer, but this has not been demonstrated. I3C has been found to be effective in treating some cases of recurrent respiratory papillomatosis, and it may have other clinical uses.
萝卜硫素的水解产物吲哚 - 3 - 甲醇（I3C）会代谢为多种产物，包括二聚体3,3'-二吲哚甲烷（DIM）。I3C和DIM都具有多种生物学和生物化学效应。这些效应大多似乎是因为I3C调节了几种核转录因子。I3C诱导参与致癌物（包括雌激素）代谢的I相和II相酶。给予I3C或DIM都会导致雌激素的2 - 羟基化增加。I3C还通过影响参与该过程的几种蛋白质来增强DNA修复。I3C诱导G1期细胞周期停滞和细胞凋亡。所有这些活性都导致抗癌作用。虽然I3C已被证明可预防某些致癌物诱导的肿瘤，但在动物模型中也观察到它会促进肿瘤发展。在人类中，I3C和DIM会影响雌激素的代谢。有人担心I3C可能会增加诱导或促进癌症的雌激素代谢物的形成，但这尚未得到证实。已发现I3C在治疗某些复发性呼吸道乳头状瘤病病例中有效，并且它可能还有其他临床用途。
