Laaksonen M S, Kivelä R, Kyröläinen H, Sipilä S, Selänne H, Lautamäki R, Nuutila P, Knuuti J, Kalliokoski K K, Komi P V
Turku PET Centre, University of Turku, Turku, Finland.
Acta Physiol (Oxf). 2006 Apr;186(4):261-70. doi: 10.1111/j.1748-1716.2006.01532.x.
The influence of exhaustive stretch-shortening cycle exercise (SSC) on skeletal muscle blood flow (BF) during exercise is currently unknown.
Quadriceps femoris (QF) BF was measured in eight healthy men using positron emission tomography before and 3 days after exhaustive SSC exercise. The SSC protocol consisted of maximal and submaximal drop jumps with one leg. Needle biopsies of the vastus lateralis muscles were taken immediately and 2 days after SSC for muscle endothelial nitric oxide synthase (eNOS) and interleukin-1-beta (IL-1beta) mRNA level determinations.
All subjects reported subjective muscle soreness after SSC (P < 0.001), which was well in line with a decrease in maximal isometric contraction force (MVC) and increase in serum creatine kinase activity (CK) (P = 0.018). After SSC muscle BF was 25% higher in entire QF (P = 0.043) and in its deep and superficial muscle regions, whereas oxygen uptake remained unchanged (P = 0.893). Muscle biopsies revealed increased IL-1beta (30 min: 152 +/- 75%, P = 0.012 and 2 days: 108 +/- 203%, P = 0.036) but decreased or unchanged eNOS (30 min; -21 +/- 57%, P = 0.050 and 2 days: +101 +/- 204%, P = 0.779) mRNA levels after SSC.
It was concluded that fatiguing SSC exercise induces increased muscle BF during exercise, which is likely to be associated with pro-inflammatory processes in the exercised muscle.
目前尚不清楚力竭性伸缩往复循环运动（SSC）对运动期间骨骼肌血流量（BF）的影响。
在8名健康男性中，于力竭性SSC运动前及运动后3天，使用正电子发射断层扫描测量股四头肌（QF）的BF。SSC方案包括单腿的最大和次最大纵跳。在SSC运动后立即及2天后，对股外侧肌进行针吸活检，以测定肌肉内皮型一氧化氮合酶（eNOS）和白细胞介素-1β（IL-1β）的mRNA水平。
所有受试者在SSC运动后均报告有主观肌肉酸痛（P < 0.001），这与最大等长收缩力（MVC）降低和血清肌酸激酶活性（CK）升高一致（P = 0.018）。SSC运动后，整个QF及其深层和浅层肌肉区域的肌肉BF增加了25%（P = 0.043），而摄氧量保持不变（P = 0.893）。肌肉活检显示，SSC运动后IL-1β增加（30分钟时：152±75%，P = 0.012；2天时：108±203%，P = 0.036），但eNOS的mRNA水平降低或未改变（30分钟时：-21±57%，P = 0.050；2天时：+101±204%，P = 0.779）。
得出的结论是，疲劳性SSC运动在运动期间会导致肌肉BF增加，这可能与运动肌肉中的促炎过程有关。
