Proesmans W, Eggermont E, Vanderschueren-Lodeweyckx M, Tiddens H, Eeckels R
Pediatr Res. 1975 May;9(5):509-12. doi: 10.1203/00006450-197505000-00009.
The administration of c-AMP and DB c-AMP to six children with NDI has failed to yield an antidiuretic effect. From the present study it may be concluded that, at the doses used, neither c-AMP nor its dibutyryl derivative can mimic the action of ADH in NDI as they do in normal subjects. On the contrary, DB c-AMP increased urine volume and Cosm in a very marked way, without changing the creatinine excretion.
对六名肾性尿崩症患儿给予环磷腺苷（c-AMP）和双丁酰环磷腺苷（DB c-AMP）未能产生抗利尿作用。从本研究可以得出结论，在所使用的剂量下，c-AMP及其双丁酰衍生物均不能像在正常受试者中那样模拟抗利尿激素（ADH）在肾性尿崩症中的作用。相反，双丁酰环磷腺苷以非常显著的方式增加尿量和菊粉清除率（Cosm），而不改变肌酐排泄。
