Gamal Gehan, Nagashima Toshiteru, Kawashima Osamu, Sugano Masayuki, Sakurai Shinji, Sano Takaaki, Nakajima Takashi
Department of Tumor Pathology, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, Japan.
Pathol Int. 2006 Apr;56(4):217-21. doi: 10.1111/j.1440-1827.2006.01949.x.
In the lung, acinic cell carcinoma (ACC) is a rare form of tumor. Reported herein is a unique bronchial gland-type tumor diagnosed as well-differentiated ACC that developed in the B9 bronchus of the left lung. Various immunohistochemical and histochemical staining partly satisfied the diagnosis of ACC. Moreover, this tumor contained various sizes of mucous cysts lined by columnar mucous cells, which produced abundant mucin positive for Alcian blue, which is usually present in mucoepidermoid carcinoma. Therefore, the present case is a unique tumor having a broad spectrum of cell differentiation from the terminal duct--acinar unit to the striated duct and excretory duct. This is the first case of unique bronchial gland-type tumor with mixed histological features of ACC and mucoepidermoid carcinoma.
在肺部，腺泡细胞癌（ACC）是一种罕见的肿瘤形式。本文报告了一例独特的支气管腺体型肿瘤，诊断为高分化ACC，发生于左肺B9支气管。各种免疫组织化学和组织化学染色部分符合ACC的诊断。此外，该肿瘤含有各种大小的黏液囊肿，内衬柱状黏液细胞，产生大量对阿尔辛蓝呈阳性的黏液，而阿尔辛蓝通常存在于黏液表皮样癌中。因此，本病例是一种独特的肿瘤，具有从终末导管 - 腺泡单位到纹状管和排泄管的广泛细胞分化谱。这是首例具有ACC和黏液表皮样癌混合组织学特征的独特支气管腺体型肿瘤。
