Williams I L, Chowienczyk P J, Wheatcroft S B, Patel A, Sherwood R, Momin A, Shah A M, Kearney M T
Cardiovascular Division, King's College, London, UK.
Diabetes Obes Metab. 2006 May;8(3):296-301. doi: 10.1111/j.1463-1326.2005.00505.x.
The present study aims to explore the relationship between inflammatory cytokines, plasma lipids, insulin, blood pressure (BP), total adiposity/markers of fat distribution and endothelial function in healthy people across a wide range of body fatness.
Seventy-three healthy people (44 women; age range: 24-64 years) with body mass index (BMI) range of 18.6-73.1 kg/m2 were recruited. All participants underwent assessment of conduit artery endothelial-dependent vasodilatation by using flow-mediated vasodilatation (FMD) of the brachial artery and endothelial-independent vasodilatation to sublingual GTN. They had blood taken for measurement of plasma markers of glucose homeostasis (fasting insulin and glucose), systemic inflammation (interleukin-6 (IL-6), C-reactive protein (CRP) and tumour necrosis factor-alpha receptor 2 (TNF-alpha R2)) and lipids (low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides). Morphometric assessment (waist circumference, BMI and waist-to-hip ratio (WHR)) and systolic and diastolic arterial pressure were also measured.
Markers of total body fat/fat distribution (waist circumference, BMI and WHR), inflammation (IL-6, CRP and TNF-alpha R2), metabolism (fasting insulin, HDL, LDL and triglycerides) and BP (systolic and diastolic) correlated with FMD. Among these measurements, WHR was the only independent predictor of FMD (r2 = 0.30; p = 0.0001).
WHR is an important marker of endothelial dysfunction in healthy people across a wide range of body fatness.
本研究旨在探讨在广泛的身体肥胖范围内，健康人群中炎症细胞因子、血脂、胰岛素、血压（BP）、总体脂/脂肪分布标志物与内皮功能之间的关系。
招募了73名健康人（44名女性；年龄范围：24 - 64岁），其体重指数（BMI）范围为18.6 - 73.1kg/m²。所有参与者通过使用肱动脉的血流介导的血管舒张（FMD）和对舌下硝酸甘油的非内皮依赖性血管舒张来评估 conduit 动脉内皮依赖性血管舒张。他们采集血液以测量葡萄糖稳态的血浆标志物（空腹胰岛素和葡萄糖）、全身炎症（白细胞介素-６（IL-６）、C反应蛋白（CRP）和肿瘤坏死因子-α受体2（TNF-αR2））以及血脂（低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和甘油三酯）。还测量了形态学评估指标（腰围、BMI和腰臀比（WHR））以及收缩压和舒张压。
总体脂/脂肪分布标志物（腰围、BMI和WHR）、炎症（IL-６、CRP和TNF-αR2）、代谢（空腹胰岛素、HDL、LDL和甘油三酯）和BP（收缩压和舒张压）与FMD相关。在这些测量指标中，WHR是FMD的唯一独立预测因子（r² = 0.30；p = 0.0001）。
在广泛的身体肥胖范围内，WHR是健康人群内皮功能障碍的重要标志物。
