Department of Diabetes and Cardiovascular Research, LIGHT Laboratories, University of Leeds, Clarendon Way, Leeds, LS2 9NL, UK.
Pflugers Arch. 2013 Aug;465(8):1065-74. doi: 10.1007/s00424-013-1218-z. Epub 2013 Jan 22.
The insulin-like growth factor-1 receptor (IGF-1R), like the insulin receptor (IR), plays a significant role in determining bioavailability of the critical signalling molecule nitric oxide (NO) and hence, modulates endothelial cell function, particularly in response to stimulation with insulin. In particular, the ability of the IGF-1R to form hybrid receptors with the IR appears to be highly significant in determining the sensitivity of the endothelial cell to insulin. This review will examine the structure of the IGF-1R and how this, with particular reference to the ability of the IGF-1R and the IR to form hybrid receptors, may have an effect both on endothelial cell function and the development of cardiovascular disease.
胰岛素样生长因子-1 受体 (IGF-1R) 与胰岛素受体 (IR) 一样，在决定关键信号分子一氧化氮 (NO) 的生物利用度方面发挥着重要作用，从而调节内皮细胞功能，特别是对胰岛素刺激的反应。特别是，IGF-1R 与 IR 形成杂合受体的能力似乎对确定内皮细胞对胰岛素的敏感性具有重要意义。这篇综述将探讨 IGF-1R 的结构，以及这种结构，特别是 IGF-1R 和 IR 形成杂合受体的能力，如何对内皮细胞功能和心血管疾病的发展产生影响。
