Karelis A D, Henry J-F, St-Pierre D H, Prud'homme D, Rabasa-Lhoret R
Department of Nutrition, Université de Montréal, Montreal, Quebec, Canada.
Diabetes Obes Metab. 2006 May;8(3):336-41. doi: 10.1111/j.1463-1326.2005.00503.x.
We investigated the relationship between insulin sensitivity and the graded increase in the number of features of the metabolic syndrome in a cross-sectional sample of obese postmenopausal women. We hypothesized that insulin sensitivity would deteriorate with an increased number of metabolic syndrome phenotypes.
Insulin sensitivity was measured in 75 obese postmenopausal women (age: 57.3 +/- 5.3 years; BMI: 32.8 +/- 4.5 kg/m2) by using both the hyperinsulinaemic-euglycaemic clamp and the homeostasis model assessment (HOMA-IR). Features of the metabolic syndrome included visceral fat (>130 cm2), HDL-cholesterol (<1.29 mmol/l), fasting triglycerides (> or =1.7 mmol/l), blood pressure (> or =130/> or =85 mmHg) and fasting glucose (> or =6.1 mmol/l). Participants were classified into three categories based on the presence of metabolic syndrome phenotypes: 0-1 vs. 2 vs. > or =3 features of the metabolic syndrome.
We found that insulin sensitivity decreased in a graded fashion (12.19 +/- 3.2 vs. 11.80 +/- 2.3 vs. 9.29 +/- 2.6 mg/min/FFM) and HOMA-IR increased in a similar manner (2.95 +/- 1.1 vs. 3.28 +/- 1.3 vs. 4.65 +/- 2.2), as the number of features of the metabolic syndrome increased from 0-1 to > or =3. When insulin sensitivity was statistically adjusted for visceral fat (as measured by computed tomography) and plasma triglycerides, the differences among groups were abolished.
These findings suggest that a decreased insulin sensitivity is associated with increased features of the metabolic syndrome in obese postmenopausal women and that visceral fat as well as plasma triglyceride accumulation might be potential mediators of this relationship.
在肥胖绝经后女性的横断面样本中，我们研究了胰岛素敏感性与代谢综合征特征数量分级增加之间的关系。我们假设胰岛素敏感性会随着代谢综合征表型数量的增加而恶化。
通过使用高胰岛素-正葡萄糖钳夹技术和稳态模型评估（HOMA-IR），对75名肥胖绝经后女性（年龄：57.3±5.3岁；体重指数：32.8±4.5kg/m²）的胰岛素敏感性进行了测量。代谢综合征的特征包括内脏脂肪（>130cm²）、高密度脂蛋白胆固醇（<1.29mmol/L）、空腹甘油三酯（≥1.7mmol/L）、血压（≥130/≥85mmHg）和空腹血糖（≥6.1mmol/L）。根据代谢综合征表型的存在情况，将参与者分为三类：代谢综合征0-1项特征组与2项特征组与≥3项特征组。
我们发现，随着代谢综合征特征数量从0-1项增加到≥3项，胰岛素敏感性呈分级下降（12.19±3.2 vs. 11.80±2.3 vs. 9.29±2.6mg/min/去脂体重），HOMA-IR也以类似方式增加（2.95±1.1 vs. 3.28±1.3 vs. 4.65±2.2）。当对胰岛素敏感性进行内脏脂肪（通过计算机断层扫描测量）和血浆甘油三酯的统计学调整后，各组之间的差异消失。
这些发现表明，肥胖绝经后女性胰岛素敏感性降低与代谢综合征特征增加有关，内脏脂肪以及血浆甘油三酯积累可能是这种关系的潜在介导因素。
