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[活体肝移植中右叶供肝者的安全性]

[Safety of donor of right lobe graft in living donor liver transplantation].

作者信息

Wen Tian-fu, Yan Lü-nan, Li Bo, Zeng Yong, Zhao Ji-chun, Wang Wen-tao, Yang Jia-yin, Ma Yu-kui, Xu Ming-qing, Chen Zhe-yu, Liu Jiang-wen, Deng Zhi-gang, Wu Hong

机构信息

Department of General surgery, West China Hospital, Sichuan University Chengdu 610041, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2006 Feb 1;44(3):149-52.

Abstract

OBJECTIVE

To evaluate the safety of donors of right lobe graft.

METHODS

We retrospectively studied 13 living donors of right lobe graft from January 2002 to June 2005. The right lobe grafts were obtained by transecting the liver on the right side of the middle hepatic vein. Liver transection was done by using an ultrasonic dissector without inflow vascular occlusion. The standard liver volume and the ratio of left lobe volume to the standard liver volume were calculated.

RESULTS

The mean blood loss was 490 ml. The mean blood transfusion was 440 ml. In the perioperative period the mean albumin administered was 85 g. One donor had portal vein trifurcation, two had a right posterior bile duct and a right anterior bile duct draining into the left bile duct, respectively. One had bile ducts from left lateral and left internal segment and right duct draining into common hepatic duct. On postoperative day 1 the donors' liver functions were found impaired to some extent, but all the indices rapidly returned to the normal level at the end of the first week. Postoperative complications included 1 case of abdominal bleeding, 2 wound steatosis and 1 chyle leak. There was no donor mortality. All donors are well and have returned to their previous occupations.

CONCLUSIONS

The donation of right lobe graft for adult living donor liver transplantation is safe provided that the patency of the remnant hepatic vasculature and bile duct is ensured, the volume of the remnant liver exceeds 30% of the total liver volume, and there is no injury to the remnant liver.

摘要

目的

评估右叶供肝者的安全性。

方法

我们回顾性研究了2002年1月至2005年6月期间13例右叶供肝的活体供者。右叶供肝通过在肝中静脉右侧横断肝脏获取。肝横断采用超声分离器进行,不进行入肝血管阻断。计算标准肝体积以及左叶体积与标准肝体积的比值。

结果

平均失血量为490毫升。平均输血量为440毫升。围手术期平均给予白蛋白85克。1例供者存在门静脉三叉分支,2例分别有右后胆管和右前胆管汇入左胆管。1例有来自左外叶和左内叶的胆管以及右胆管汇入肝总管。术后第1天发现供者肝功能有一定程度受损,但所有指标在第一周结束时迅速恢复至正常水平。术后并发症包括1例腹腔出血、2例伤口脂肪变性和1例乳糜漏。无供者死亡。所有供者情况良好,已恢复原工作。

结论

对于成人活体供肝肝移植,只要确保残余肝血管和胆管通畅,残余肝体积超过全肝体积的30%,且残余肝无损伤,右叶供肝的捐献就是安全的。

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