Kalman Bernadette
Department of Neurology, Saint Luke's Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY 10019, USA.
Curr Neurol Neurosci Rep. 2006 May;6(3):244-52. doi: 10.1007/s11910-006-0012-0.
This review presents inherited and acquired forms of mitochondrial dysfunction associated with oligodendrocytopathy and neurodegeneration in order to better understand the degenerative features of inflammatory demyelination. The recognition that various mitochondrial mechanisms are involved in the pathogenesis of multiple sclerosis leads to therapeutic considerations, re-emphasizing the importance of early neuroprotection in combination with the approved means of immune modulation.
本综述介绍了与少突胶质细胞病变和神经退行性变相关的线粒体功能障碍的遗传和获得性形式，以便更好地理解炎性脱髓鞘的退行性特征。认识到多种线粒体机制参与多发性硬化症的发病机制引发了治疗方面的考虑，再次强调了早期神经保护与已批准的免疫调节方法相结合的重要性。
