Margel David, Shochat Tamar, Getzler Ofir, Livne Pinhas M, Pillar Giora
Institute of Urology, Rabin Medical Center, Petah Tiqva, Israel.
Urology. 2006 May;67(5):974-7. doi: 10.1016/j.urology.2005.11.054. Epub 2006 Apr 25.
To examine whether treatment with continuous positive airway pressure (CPAP) reduces nocturia in patients with obstructive sleep apnea (OSA).
This prospective clinical study recruited patients referred to the Rambam Sleep Laboratory with suspected OSA. After polysomnography, those found to have no OSA were excluded from the study, and the remainder were treated with CPAP. Nocturia was assessed at four time points: baseline (average number of awakenings to urinate per night during 1 week at home before polysomnography); diagnostic night in the laboratory; CPAP titration in the laboratory; and after 1 to 3 months of stable CPAP treatment at home (average number of awakenings to urinate per night for 1 week).
Ninety-seven patients (75 men and 22 women) completed the study. The mean +/- SD age was 55 +/- 12 years, body mass index was 33 +/- 7 kg/m2, and respiratory disturbance index was 34 +/- 24/hr. The mean number of awakenings to void at home before CPAP was 2.5 +/- 2.4 times/night; during CPAP, it was 0.7 +/- 0.6 time/night (P < 0.001). A total of 73 patients reported improvement in nocturia. The mean number of awakenings to void in the laboratory was 1.1 +/- 0.9 before CPAP, with a decrease to 0.5 +/- 0.6 during CPAP (P < 0.001). Weak, but significant, correlations were found in the number of awakenings to void before treatment with the respiratory disturbance index (r = 0.25, P = 0.01) and with minimal oxygen saturation (r = -0.23, P = 0.02).
CPAP appears to be an effective treatment for nocturia associated with OSA.
探讨持续气道正压通气（CPAP）治疗能否减少阻塞性睡眠呼吸暂停（OSA）患者的夜尿症。
这项前瞻性临床研究招募了转诊至兰巴姆睡眠实验室、疑似患有OSA的患者。经多导睡眠图检查后，将未患OSA的患者排除在研究之外，其余患者接受CPAP治疗。在四个时间点评估夜尿症情况：基线期（多导睡眠图检查前在家中1周每晚平均夜尿觉醒次数）；实验室诊断夜；实验室CPAP滴定；以及在家中接受1至3个月稳定CPAP治疗后（1周每晚平均夜尿觉醒次数）。
97例患者（75例男性和22例女性）完成了研究。平均年龄±标准差为55±12岁，体重指数为33±7kg/m²，呼吸紊乱指数为34±24次/小时。CPAP治疗前在家中平均夜尿觉醒次数为2.5±2.4次/夜；CPAP治疗期间为0.7±0.6次/夜（P<0.001）。共有73例患者报告夜尿症有所改善。CPAP治疗前在实验室平均夜尿觉醒次数为1.1±0.9次，CPAP治疗期间降至0.5±0.6次（P<0.001）。治疗前夜尿觉醒次数与呼吸紊乱指数（r=0.25，P=0.01）和最低氧饱和度（r=-0.23，P=0.02）之间存在弱但显著的相关性。
CPAP似乎是治疗与OSA相关的夜尿症的有效方法。
