Grant Judith, Cranston Amy, Horsman John, Furlong William, Barr Neil, Findlay Sheri, Barr Ronald
Faculty of Medicine, University of Aberdeen, Aberdeen, Scotland.
J Adolesc Health. 2006 May;38(5):504-10. doi: 10.1016/j.jadohealth.2005.08.002.
Adolescent survivors of cancer in childhood face particular challenges due to their maturational trajectory, including psychosocial adjustments, self-help skills, intellectual functioning and socialization. To better understand these, we assessed the health status and health-related quality of life (HRQL) in a 20-year cohort of such survivors in a single institution.
Health status and HRQL were measured with a self-complete questionnaire from the Health Utilities Index (HUI) family of multi-attribute, preference-based instruments that provide utility scores for single attributes and overall HRQL.
Eighty-four (42 males, 42 females) of 129 eligible subjects (65%) participated. More than 80% of the respondents reported some form of morbidity. Overall HRQL utility scores were lower for both the males and females than for corresponding members of the Canadian general population. Female survivors self-reported a significantly greater burden of morbidity (mean overall HUI2/HUI3 scores: .83/.73 vs. .90/.84 for males, p < .02), which was most evident in the attributes of emotion and cognition.
The majority of adolescent survivors of cancer in childhood carry a morbidity burden into their teen and young adult years. These findings may guide the support required by this population.
童年期癌症的青少年幸存者因其成长轨迹面临特殊挑战，包括心理社会适应、自助技能、智力功能和社交能力。为更好地了解这些情况，我们在一家单一机构中对这样一组20年队列的幸存者的健康状况和健康相关生活质量（HRQL）进行了评估。
使用来自健康效用指数（HUI）系列多属性、基于偏好的工具的自填问卷来测量健康状况和HRQL，该工具可为单一属性和总体HRQL提供效用分数。
129名符合条件的受试者中有84名（42名男性，42名女性）（65%）参与。超过80%的受访者报告有某种形式的疾病。男性和女性的总体HRQL效用分数均低于加拿大普通人群的相应成员。女性幸存者自我报告的疾病负担明显更大（总体HUI2/HUI3平均分数：男性为0.83/0.73，女性为0.90/0.84，p < 0.02），这在情绪和认知属性方面最为明显。
大多数童年期癌症的青少年幸存者在青少年和青年时期都背负着疾病负担。这些发现可能为该人群所需的支持提供指导。
