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A.V. Circulo对异丙肾上腺素诱导的心肌坏死的心脏保护作用。

Cardioprotective activity of A.V. Circulo in isoproterenol-induced myocardial necrosis.

作者信息

Chauhan Gauri Madhav, Naik Suresh R

机构信息

Principal K.M. Kundanani College of Pharmacy, Mumbai University, Mumbai, India.

出版信息

J Herb Pharmacother. 2005;5(4):51-61.

Abstract

Cardioprotective activity of A.V. Circulo, a polyherbal preparation, was evaluated in isoproterenol induced myocardial damage in rats. Chronic prophylactic treatment with A.V. Circulo prevented an increase in serum lysosomal enzyme activity of creatinine phosphokinase, lactate dehydrogenase, and serum glutamate oxaloacetic transaminase in the blood due to isoproterenol administration. A.V. Circulo treatment also significantly inhibited increases in DNA and protein content in heart tissue as well as elevated serum lipid levels after isoproterenol administration. Treatment was also able to inhibit the isoproterenol induced increase in heart weight to body weight ratio. Pretreatment with the polyherbal restored the altered architectural changes in the histology of myocardium, due to isoproterenol administration. All findings, including biological, biochemical, and histopathological indicate that A.V. Circulo treatment chronically protected the cardiac injury.

摘要

对一种多草药制剂A.V. Circulo在异丙肾上腺素诱导的大鼠心肌损伤中的心脏保护活性进行了评估。用A.V. Circulo进行慢性预防性治疗可防止因给予异丙肾上腺素而导致血液中血清溶酶体酶(肌酸磷酸激酶、乳酸脱氢酶和血清谷氨酸草酰乙酸转氨酶)活性增加。A.V. Circulo治疗还显著抑制了异丙肾上腺素给药后心脏组织中DNA和蛋白质含量的增加以及血清脂质水平的升高。该治疗还能够抑制异丙肾上腺素诱导的心脏重量与体重比的增加。用这种多草药进行预处理可恢复因给予异丙肾上腺素而导致的心肌组织学结构改变。所有包括生物学、生物化学和组织病理学在内的研究结果均表明,A.V. Circulo治疗可长期保护心脏免受损伤。

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