脑出血后的长期死亡率。

Long-term mortality after intracerebral hemorrhage.

作者信息

Flaherty M L, Haverbusch M, Sekar P, Kissela B, Kleindorfer D, Moomaw C J, Sauerbeck L, Schneider A, Broderick J P, Woo D

机构信息

Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267-0525, USA.

出版信息

Neurology. 2006 Apr 25;66(8):1182-6. doi: 10.1212/01.wnl.0000208400.08722.7c.

DOI:10.1212/01.wnl.0000208400.08722.7c

PMID:16636234

Abstract

OBJECTIVE

To characterize long-term mortality following intracerebral hemorrhage (ICH) in two large population-based cohorts assembled more than a decade apart.

METHODS

All patients age > or = 18 hospitalized with nontraumatic ICH in the Greater Cincinnati/Northern Kentucky area were identified during 1988 (Cohort 1) and from May 1998 to July 2001 and August 2002 to April 2003 (Cohort 2). Mortality was tabulated using actuarial methods and compared with a log-rank test.

RESULTS

There were 183 patients with ICH in Cohort 1 and 1,041 patients in Cohort 2. Patients in Cohort 1 were more likely to be white (p = 0.024) and undergo operation for their ICH (p = 0.002), whereas patients in Cohort 2 were more commonly on anticoagulants (p < 0.001). Among patients in Cohort 1, mortality at 7 days, 1 year, and 10 years was 31, 59, and 82%. Among patients in Cohort 2, mortality at 7 days and 1 year was 34 and 53%. Mortality rates did not differ between cohorts by log-rank test (p = 0.259).

CONCLUSIONS

Intracerebral hemorrhage (ICH) mortality did not improve significantly between study periods. Operation for ICH became less frequent, whereas anticoagulant-associated ICH became more common.

摘要

目的

在间隔超过十年收集的两个大型基于人群的队列中，描述脑出血（ICH）后的长期死亡率。

方法

1988年（队列1）以及1998年5月至2001年7月和2002年8月至2003年4月期间，在大辛辛那提/北肯塔基地区，确定所有年龄≥18岁因非创伤性ICH住院的患者。使用精算方法将死亡率制成表格，并通过对数秩检验进行比较。

结果

队列1中有183例ICH患者，队列2中有1,041例患者。队列1中的患者更可能是白人（p = 0.024）并且因ICH接受手术（p = 0.002），而队列2中的患者更常使用抗凝剂（p < 0.001）。在队列1的患者中，7天、1年和10年的死亡率分别为31%、59%和82%。在队列2的患者中，7天和1年的死亡率分别为34%和53%。通过对数秩检验，各队列之间的死亡率没有差异（p = 0.259）。