单核细胞趋化蛋白-1与HIV感染中的皮质下脑损伤相关。
Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection.
作者信息
Ragin A B, Wu Y, Storey P, Cohen B A, Edelman R R, Epstein L G
机构信息
Department of Radiology, The Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
出版信息
Neurology. 2006 Apr 25;66(8):1255-7. doi: 10.1212/01.wnl.0000208433.34723.65.
Abstract
Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-alpha) and putamen (hematocrit).
摘要
多种生物标志物已被认为与HIV相关神经认知障碍有关联或具有预测性。评估了血浆单核细胞趋化蛋白1（MCP-1）、肿瘤坏死因子α（TNF-α）水平以及血细胞比容与半卵圆中心、尾状核和壳核的扩散张量成像测量值之间的关系。MCP-1水平与所有检查区域的组织状态（平均扩散率）相关。血浆标志物也与半卵圆中心（TNF-α）和壳核（血细胞比容）的各向异性测量值显著相关。
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