Bakhtadze M G, Margvelashvili V V, Kamkamidze G K
Georgian Med News. 2006 Mar(132):30-3.
The aim of the study was to compare the serum levels of interferon-gamma (INF-gamma) and neopterin (NPT) in 10 patients with mild form of chronic periodontitis before and after operations. Overall objective of these operations is the elimination of periodontal and osseous pockets. 10 blood donors were included in the control group. The serum levels of INF-gamma and NPT were measured using enzyme immunoassay technique. INF-gamma and neopterin in patients with chronic periodontitis were assessed before and 4 to 6 weeks after the operation. The mean serum INF-gamma in patients with mild form of chronic periodontitis (n=10) was 13,2+/-4,03 pg/mL. The mean serum INF-gamma level in patients with mild form of chronic periodontitis (n=10) after the operations was 10,05+/-3,12 pg/mL. Serum levels of INF-gamma in patients with mild form chronic periodontitis were significantly higher than those in the control group. There was no significant difference in serum levels of INF-gamma in patients with mild form before and after operations. The mean serum level of NPT in the control was 5,3+/-2,39 nmol/L. The mean serum NPT level in patients (n=10) with mild form chronic parodontitis was 14,4+/-10,05 nmol/L. After operations NPT concentration were reduced (6,9+/-3,39 nmol/L). Serum levels of NTP in patients with mild form chronic periodontitis were significantly higher than those in the control group. Significant difference was observed in serum levels of NPT in patients with mild form of chronic periodontitis before and after operations. Obtained data allow specifying the mechanism of positive influence of autograft operations on the pathogenesis of chronic periodontitis.
本研究的目的是比较10例轻度慢性牙周炎患者手术前后血清中γ-干扰素（INF-γ）和新蝶呤（NPT）的水平。这些手术的总体目标是消除牙周袋和骨袋。对照组纳入10名献血者。采用酶免疫测定技术测量血清中INF-γ和NPT的水平。对慢性牙周炎患者在手术前以及术后4至6周评估INF-γ和新蝶呤水平。轻度慢性牙周炎患者（n = 10）的血清INF-γ平均水平为13.2±4.03 pg/mL。手术后轻度慢性牙周炎患者（n = 10）的血清INF-γ平均水平为10.05±3.12 pg/mL。轻度慢性牙周炎患者的血清INF-γ水平显著高于对照组。轻度慢性牙周炎患者手术前后血清INF-γ水平无显著差异。对照组血清NPT平均水平为5.3±2.39 nmol/L。轻度慢性牙周炎患者（n = 10）的血清NPT平均水平为14.4±10.05 nmol/L。手术后NPT浓度降低（6.9±3.39 nmol/L）。轻度慢性牙周炎患者的血清NTP水平显著高于对照组。观察到轻度慢性牙周炎患者手术前后血清NPT水平存在显著差异。获得的数据有助于明确自体移植手术对慢性牙周炎发病机制产生积极影响的机制。
