曲霉CCAAT结合蛋白亚基中与酿酒酵母Hap5p的HAP4p募集结构域相似的区域对转录增强并非必需。
The region in a subunit of the Aspergillus CCAAT-binding protein similar to the HAP4p-recruiting domain of Saccharomyces cerevisiae Hap5p is not essential for transcriptional enhancement.
作者信息
Tanoue Shinjiro, Kamei Ken-ichi, Goda Hideya, Tanaka Akimitsu, Kobayashi Tetsuo, Tsukagoshi Norihiro, Kato Masashi
机构信息
Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
出版信息
Biosci Biotechnol Biochem. 2006 Apr;70(4):782-7. doi: 10.1271/bbb.70.782.
The CCAAT-binding complex in Aspergillus species, known as the Hap complex, consists of at least three subunits, HapB, HapC, and HapE. Each Hap subunit contains an evolutionarily conserved core domain. In this study, a series of the truncated gene, which encodes the HapE subunit of Aspergillus oryzae, was constructed to survey the regions essential for the transcriptional enhancement of fungal genes. It was revealed that the non-conserved regions and the conserved region similar to the Hap4p recruiting domain of Saccharomyces cerevisiae were not necessary for Hap complex-mediated transcriptional enhancement.
曲霉属物种中与CCAAT结合的复合物，即Hap复合物，至少由三个亚基HapB、HapC和HapE组成。每个Hap亚基都包含一个进化上保守的核心结构域。在本研究中，构建了一系列编码米曲霉HapE亚基的截短基因，以探究真菌基因转录增强所必需的区域。结果表明，非保守区域以及与酿酒酵母Hap4p募集结构域相似的保守区域对于Hap复合物介导的转录增强并非必需。
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