Denning D W, Armstrong R W, Fishman M, Stevens D A
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128.
Rev Infect Dis. 1991 Nov-Dec;13(6):1126-30. doi: 10.1093/clinids/13.6.1126.
We report a case of presumed cryptococcal endophthalmitis that occurred in a patient with severe disseminated cryptococcosis and AIDS. Multiple small, spherical lesions appeared bilaterally on the surface of the retina 2 weeks after cryptococcal meningitis was diagnosed; the lesions were associated with multiple blind spots, blurred vision, and the perception of flaring of light. Over the next week, many more lesions with adjacent hemorrhages appeared. Therapy with itraconazole over the next 3 months resulted in complete resolution of the lesions. Cryptococcal endophthalmitis is a rare disease. Fewer than 20 cases, including five in patients with AIDS, have previously been reported. None of these patients regained normal vision.
我们报告一例推测为新型隐球菌性眼内炎的病例，该病例发生在一名患有严重播散性新型隐球菌病和艾滋病的患者身上。在诊断为新型隐球菌性脑膜炎2周后，双侧视网膜表面出现多个小的球形病变；这些病变与多个盲点、视力模糊以及光闪烁感有关。在接下来的一周内，出现了更多伴有相邻出血的病变。在接下来的3个月里，使用伊曲康唑治疗使病变完全消退。新型隐球菌性眼内炎是一种罕见疾病。此前报道的病例不到20例，其中包括5例艾滋病患者。这些患者均未恢复正常视力。
