Shroff Hemal, Reba Lauren, Thornton Laura M, Tozzi Federica, Klump Kelly L, Berrettini Wade H, Brandt Harry, Crawford Steven, Crow Scott, Fichter Manfred M, Goldman David, Halmi Katherine A, Johnson Craig, Kaplan Allan S, Keel Pamela, LaVia Maria, Mitchell James, Rotondo Alessandro, Strober Michael, Treasure Janet, Woodside D Blake, Kaye Walter H, Bulik Cynthia M
Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, and Center for Eating Disorders at Sheppard and Enoch Pratt Hospital, Towson, MD, USA.
Int J Eat Disord. 2006 Sep;39(6):454-61. doi: 10.1002/eat.20247.
Excessive exercise and motor restlessness are observed in a substantial number of patients with eating disorders. This trait has been studied extensively among animal models of activity anorexia nervosa (AN) and may hold particular interest as an endophenotype for AN. We explored features associated with excessive exercise across subtypes of eating disorders.
Participants were female probands and affected female relatives from the multi-site international Price Foundation Genetic Studies with diagnoses of AN, bulimia nervosa (BN), and both AN and BN or eating disorder not otherwise specified (ED-NOS) (N=1,857). Excessive exercise was defined based on responses to the Structured Interview for Anorexic and Bulimic Disorders (SIAB).
Among the eating disorder diagnostic groups, excessive exercise was most common among the purging subtype of AN. Individuals who reported excessive exercise also reported lower minimum BMI, younger age at interview, higher scores on anxiety, perfectionism, and eating disorder symptom measures, more obsessions and compulsions, and greater persistence.
Excessive exercise may be associated particularly with the purging subtype of AN as well as with a constellation of anxious/obsessional temperament and personality characteristics among women with eating disorders.
在大量饮食失调患者中观察到过度运动和运动不安。这一特征在神经性厌食活动模型（AN）的动物模型中已得到广泛研究，并且作为AN的一种内表型可能具有特殊意义。我们探讨了饮食失调各亚型中与过度运动相关的特征。
参与者为来自多中心国际普莱斯基金会遗传学研究的女性先证者及其受影响的女性亲属，她们被诊断为神经性厌食症（AN）、神经性贪食症（BN）、同时患有AN和BN或未另行指定的饮食失调（ED-NOS）（N = 1857）。过度运动是根据对神经性厌食和贪食症结构化访谈（SIAB）的回答来定义的。
在饮食失调诊断组中，过度运动在AN的清除亚型中最为常见。报告过度运动的个体还报告了更低的最低体重指数、访谈时更年轻的年龄、焦虑、完美主义和饮食失调症状测量的更高分数、更多的强迫观念和强迫行为以及更强的坚持性。
过度运动可能特别与AN的清除亚型相关，也与饮食失调女性的一系列焦虑/强迫性气质和人格特征相关。
