短期口服植物雌激素补充剂对前列腺癌患者下丘脑-垂体-睾丸轴的影响。

The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients.

作者信息

Rannikko Antti, Petas Anssi, Raivio Taneli, Jänne Olli A, Rannikko Sakari, Adlercreutz Herman

机构信息

Department of Urology, Helsinki University Central Hospital, Helsinki, Finland.

出版信息

Prostate. 2006 Jul 1;66(10):1086-91. doi: 10.1002/pros.20437.

DOI:10.1002/pros.20437

PMID:16637075

Abstract

BACKGROUND

Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic-pituitary-testicular (HPT) axis in CaP patients.

METHODS

We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Serum hormone levels were measured before and after treatment. In addition, recombinant cell bioassay was used to measure serum androgen bioactivity (ABA).

RESULTS

Phytoestrogen treatment increased serum LH from mean of 3.4-5.2 IU, P = 0.03. Concomitantly, non-significant trend towards decline in serum T, cfT and ABA values was noted. However, mean serum LH/T ratio was upregulated from 0.20 to 0.48 IU/nM, P = 0.004, suggesting compensated hypogonadism. During the course of treatment, serum concentration of equol correlated strongly with the concomitant decrease in ABA (r = -0.586, P = 0.022).

CONCLUSIONS

Phytoestrogen treatment interferes with HPT axis in CaP patients by inducing testicular resistance to LH and compensated hypogonadism.

摘要

背景

在此，我们评估口服植物雌激素补充剂对前列腺癌（CaP）患者下丘脑 - 垂体 - 睾丸（HPT）轴的影响。

方法

我们招募了40名即将接受前列腺癌根治术的男性，让他们每天服用240毫克三叶草植物雌激素或安慰剂，持续2周。在治疗前后测量血清激素水平。此外，使用重组细胞生物测定法测量血清雄激素生物活性（ABA）。

结果

植物雌激素治疗使血清促黄体生成素（LH）从平均3.4国际单位升高至5.2国际单位，P = 0.03。同时，观察到血清睾酮（T）、计算睾酮（cfT）和ABA值有下降的非显著趋势。然而，血清LH/T平均比值从0.20上调至0.48国际单位/纳摩尔，P = 0.004，提示存在代偿性性腺功能减退。在治疗过程中，雌马酚血清浓度与ABA的相应降低密切相关（r = -0.586，P = 0.022）。