Gordon R Ia, Ignat'ev D A, Mel'nikova E V, Rogachevskaĭ V V, Kraev I V, Khutsian S S
Biofizika. 2006 Mar-Apr;51(2):316-23.
It was shown by fluorescent and electron microscopy that the physiological state of ground squirrels subjected to ionizing radiation at different phases of the torpor-normothermia cycle plays a determining role in the alteration of the conditions of the protein-synthesizing system in neurons of hippocampus fields CA1 and CA3 and sensomotor area of the brain. In ground squirrels irradiated under normothermia, the neurons were less radioresistant and restored slower compared with torpor animal cells, the distinctions being most expressed in CA1 field neurons. The effect of irradiation was minimum during the entrance into torpor and maximum during arousal. It was supposed that the inhibition of protein synthesis in the latter case occurred at the elongation stage when heavy polyribosomes were formed in neuron cytoplasm.
荧光显微镜和电子显微镜显示，在蛰伏-正常体温循环的不同阶段受到电离辐射的地松鼠的生理状态，在海马体CA1区和CA3区神经元以及大脑感觉运动区蛋白质合成系统条件的改变中起决定性作用。与蛰伏动物细胞相比，在正常体温下接受辐射的地松鼠神经元对辐射的抵抗力较弱，恢复也较慢，这种差异在CA1区神经元中最为明显。辐射的影响在进入蛰伏期时最小，在苏醒期时最大。据推测，在后一种情况下，蛋白质合成的抑制发生在延伸阶段，此时神经元细胞质中形成了大量多核糖体。
