人下颌下腺中表皮生长因子受体的亚细胞定位
Subcellular localization of epidermal growth factor receptor in human submandibular gland.
作者信息
Lantini M S, Cossu M, Isola M, Piras M, Piludu M
机构信息
Dipartimento di Citomorfologia, Università di Cagliari, Italy.
出版信息
J Anat. 2006 May;208(5):595-9. doi: 10.1111/j.1469-7580.2006.00568.x.
Abstract
The subcellular distribution of the epidermal growth factor receptor (EGFr) was demonstrated in the normal human submandibular gland by means of immunogold cytochemistry. EGFr labelling appeared in both acinar and ductal cells, where strong immunoreactivity was associated with a tubulovesicular system near the basolateral surfaces. In addition, groups of reactive vesicles were highlighted among secretory granules of both serous and mucous cells and at the apex of ductal cells. Basolateral vesicles were interpreted as being a result of EGFr internalization after activation by an exogenous ligand, although the functional meaning of those located apically remains unclear.
摘要
通过免疫金细胞化学方法，在正常人类下颌下腺中证实了表皮生长因子受体（EGFr）的亚细胞分布。EGFr标记出现在腺泡细胞和导管细胞中，其中强免疫反应性与基底外侧表面附近的微管泡系统相关。此外，在浆液性和黏液性细胞的分泌颗粒之间以及导管细胞的顶端突出显示出反应性囊泡群。基底外侧囊泡被解释为外源性配体激活后EGFr内化的结果，尽管顶端囊泡的功能意义仍不清楚。
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