Walss-Bass C, Raventos H, Montero A P, Armas R, Dassori A, Contreras S, Liu W, Medina R, Levinson D F, Pereira M, Leach R J, Almasy L, Escamilla M A
Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA.
Acta Psychiatr Scand. 2006 Apr;113(4):314-21. doi: 10.1111/j.1600-0447.2005.00631.x.
This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia.
Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland.
The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P-value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over-transmitted to persons with a history of manic psychosis.
These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings.
本研究以哥斯达黎加中央山谷（CVCR）人群为研究对象，采用与《精神疾病诊断与统计手册》第四版（DSM-IV）分类不同的表型分析策略，探讨神经调节蛋白1与精神分裂症的关联。
我们选取了134个有精神病家族史的三联体家庭，对最初在冰岛确定的与精神分裂症相关的7个标记中的6个进行基因分型。
在CVCR人群中，冰岛型神经调节蛋白单倍型与精神分裂症无关联。然而，发现一种新的单倍型在功能性精神病患者中过度出现（总体P值>0.05）。根据躁狂病史对样本进行分层分析表明，这种单倍型可能更倾向于传递给有躁狂性精神病病史的人。
这些结果表明，在CVCR人群中，神经调节蛋白1基因不太可能在精神分裂症的易感性中起主要作用。为证实这些发现，应在CVCR人群和其他拉丁美洲人群中开展进一步研究。
