Yu Min-bin, Huang Sheng-song, Ge Jian, Guo Jiang, Fang Min
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Zhonghua Yan Ke Za Zhi. 2006 Jan;42(1):27-31.
To evaluate the efficacy and safety of endoscopic cyclophotocoagulation (ECP) in the management of refractory glaucoma.
ECP procedures were performed on fifty-one eyes of 47 patients with refractory glaucoma by using the Microprobe (Endo Optiks, URAM E2) integrated laser endoscope system. All patients were followed-up from 6 to 16 months (mean 10.8 months), with four eyes receiving a second treatment. The changes of intraocular pressure (IOP), visual acuity and complication were pre- and post-operatively observed.
Compared to preoperation, the IOP of postoperation was significantly (P < 0.01) decreased at week 1, 4, 12, and 24 [(35.3 +/- 13.0) mm Hg (1 mm Hg = 0.133 kPa) vs (19.9 +/- 13.2) mm Hg, (22.0 +/- 11.6) mm Hg, (17.6 +/- 11.6) mm Hg, and (17.0 +/- 10.4) mm Hg, x +/- s, respectively]. The mean number of IOP-decreased drugs used was significantly (P < 0.01) reduced from 3.3 to 1.0 of postoperation. 51.0% of all 51 eyes with the postoperative IOP less than 21 mm Hg did not receive any drug, and 25.5% with supplemental drug treatment. The visual acuity was significantly (P < 0.01) improved postoperatively. Postoperative hyphema were found in 4 eyes, fibrous exudates in 23 eyes, and exudative choroids detachment in 2 eyes, all of which occurred at the early postoperative stage and were healed within 2-16 days. No other complications were observed.
ECP is a safe and effective procedure for the management of refractory glaucoma without serious complications.
评估内镜睫状体光凝术（ECP）治疗难治性青光眼的有效性和安全性。
使用Microprobe（Endo Optiks，URAM E2）一体式激光内镜系统对47例难治性青光眼患者的51只眼进行ECP手术。所有患者随访6至16个月（平均10.8个月），4只眼接受了二次治疗。术前和术后观察眼压（IOP）、视力和并发症的变化。
与术前相比，术后第1、4、12和24周IOP显著降低（P < 0.01）[分别为(35.3 ± 13.0) mmHg（1 mmHg = 0.133 kPa）对(19.9 ± 13.2) mmHg、(22.0 ± 11.6) mmHg、(17.6 ± 11.6) mmHg和(17.0 ± 10.4) mmHg，x ± s]。术后使用的降低IOP药物的平均数量从3.3显著减少至1.0（P < 0.01）。51只眼中术后IOP低于21 mmHg的51.0%未接受任何药物治疗，25.5%接受了辅助药物治疗。术后视力显著改善（P < 0.01）。4只眼出现术后前房积血，23只眼出现纤维渗出，2只眼出现渗出性脉络膜脱离，均发生在术后早期，2至16天内愈合。未观察到其他并发症。
ECP是治疗难治性青光眼的一种安全有效的方法，无严重并发症。
