Chen Zuo-quan, Deng Dong-feng, Gu Bin-xian, Han Hong-Jie, Pan Qing-gang, Hai Jian, Wang Fei
Cerebral Vascular Disease Treatment Center, Tongji University, Shanghai 200065, China.
Zhonghua Yi Xue Za Zhi. 2006 Jan 17;86(3):157-9.
To evaluate the efficacy of treatment of dural arteriovenous fistula (DAVF) by transarterial embolization with low dose of N-butyl-2-cyanoacrylate (NBCA).
Eighteen patients, 6 males and 12 females, aged 47.5 (23-72), with DAVF, 12 with carotid cavernous fistula and 6 with fistula in parietal lobe, underwent transarterial embolization with low dose of NBCA (10%-20%). The key point of transarterial embolization with low dose of NBCA was that low dose NBCA was injected and embolized the veins and then was reversed into the other supplying arteries.
Seventeen patients with DAVF in cavernous region and 6 patients with DAVF in parietal lobe were cured anatomically, with the clinical syndromes disappearing. In 1 patient with DAVF in cavernous region the clinical syndrome were moderately improved after transarterial embolization, however, worsened 2 days later. Cerebrovascular angiography demonstrated that the vein was not completely embolized and the draining vein was broadened, and the clinical syndromes were moderately improved again after carotid artery compression therapy for 10 days.
Convenient and fast, and with low cost and satisfying efficacy, transarterial embolization with low dose of NBCA is a better choice for treatment of DAVF in some cases. The key point of this approach is that the tip of microcatheter is close as much as possible to the fistulae, and NBCA is injected into the fistulae and make the vein diffused well. Attention should be paid to avoid dangerous anastomosis.
评估低剂量N-丁基-2-氰基丙烯酸酯(NBCA)经动脉栓塞治疗硬脑膜动静脉瘘(DAVF)的疗效。
18例DAVF患者,男6例,女12例,年龄47.5岁(23 - 72岁),其中12例为海绵窦瘘,6例为顶叶瘘,接受低剂量(10% - 20%)NBCA经动脉栓塞治疗。低剂量NBCA经动脉栓塞的关键在于注入低剂量NBCA栓塞静脉,然后反流至其他供血动脉。
17例海绵窦区DAVF患者及6例顶叶DAVF患者解剖治愈,临床症状消失。1例海绵窦区DAVF患者经动脉栓塞后临床症状中度改善,但2天后加重。脑血管造影显示静脉未完全栓塞,引流静脉增宽,经颈动脉压迫治疗10天后临床症状再次中度改善。
低剂量NBCA经动脉栓塞治疗DAVF方便快捷、成本低且疗效满意,在某些情况下是较好的选择。该方法的关键是微导管尖端尽可能靠近瘘口,将NBCA注入瘘口并使静脉充分弥散。应注意避免危险吻合。