Chandrakasan G, Bhatnagar R S
Central Leather Research Institute, Madras, India.
Cell Mol Biol. 1991;37(7):751-5.
Exposure of diploid fetal human fibroblasts (IMR-90) to superoxide generated by dihydroxyfumarate resulted in increased collagen synthesis. The synthesis of type III collagen was stimulated to a greater extent than the synthesis of type I collagen. The stimulation of collagen synthesis was abolished by superoxide dismutase. Our observations suggest that superoxide may play a role in the regulation of collagen synthesis and may modulate differential collagen gene expression. These observations may explain the increased synthesis of collagen in tissues following inflammation or exposure to oxidant conditions.
将二倍体人胎儿成纤维细胞（IMR - 90）暴露于由二羟基富马酸盐产生的超氧化物中，会导致胶原蛋白合成增加。III型胶原蛋白的合成比I型胶原蛋白的合成受到更大程度的刺激。超氧化物歧化酶可消除对胶原蛋白合成的刺激作用。我们的观察结果表明，超氧化物可能在胶原蛋白合成的调节中发挥作用，并可能调节不同胶原蛋白基因的表达。这些观察结果可能解释了炎症后或暴露于氧化条件下组织中胶原蛋白合成增加的现象。
