Yuan Yu-hui, Dong Xin-ming, Yu Hong-wei, Guan Jun-hong, Wang Cheng-lin
Department of Neurosurgery, the Second Affiliated Hospital, China Medical University, Shenyang 110004, China.
Zhonghua Wai Ke Za Zhi. 2006 Mar 15;44(6):416-9.
To estimate the efficacy of Gamma knife radiosurgery (GKR) especially as a primary surgical treatment for hypersecreting pituitary adenoma.
One hundred and twenty cases with hypersecreting pituitary adenoma had been treated by Gamma knife radiosurgery. The clinical date had been analysed retrospectively. The tumor margin was covered by an isodose ranging from 45% to 70%. The margin dose was 15 to 32 Gy (mean 28.5 Gy) and the maximum dose varied from 35 to 70 Gy (mean 45.5 Gy). The total number of isocenter was 165 (mean 1-3).
One hundred and eleven cases had been followed-up by hormone level, and 104 cases had been followed-up by image of MRI. The mean follow-up duration was 12-72 months (mean 36 months). The control rate of hormone level was 48.6%, the control rate of tumor growth was 96.2%, the incidence of hypopituitarism was in 2.7% and the incidence of tumor apoplexy was in 0.9% in followed-up cases.
As a primary surgical treatment for hypersecreting pituitary adenoma, GKR can be effective and safe in controlling tumor growth and inducing hormonal normalization.
评估伽玛刀放射外科治疗（GKR）作为分泌性垂体腺瘤主要手术治疗方法的疗效。
120例分泌性垂体腺瘤患者接受了伽玛刀放射外科治疗。对临床资料进行回顾性分析。肿瘤边缘接受45%至70%的等剂量线覆盖。边缘剂量为15至32 Gy（平均28.5 Gy），最大剂量为35至70 Gy（平均45.5 Gy）。等中心点总数为165个（平均1 - 3个）。
111例患者进行了激素水平随访，104例患者进行了MRI影像随访。平均随访时间为12至72个月（平均36个月）。随访病例中激素水平控制率为48.6%，肿瘤生长控制率为96.2%，垂体功能减退发生率为2.7%，肿瘤卒中发生率为0.9%。
作为分泌性垂体腺瘤的主要手术治疗方法，伽玛刀放射外科治疗在控制肿瘤生长和促使激素水平恢复正常方面可以是有效且安全的。
