疟原虫对辅酶A的需求：正常鸭红细胞和感染了诺氏疟原虫的红细胞中辅酶A生物合成的酶。
Coenzyme A requirement of malaria parasites: enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae.
作者信息
Brohn F H, Trager W
出版信息
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2456-8. doi: 10.1073/pnas.72.6.2456.
Abstract
Normal duck erythrocytes and erythrocytes infected with Plasmodium lopharae have all of the enzymes for coenzyme A biosynthesis, whereas parasites freed from their host cells have non. Since erythrocytefree cultivation of P. lophurae requires an exogenous source of coenzyme A, this parasite must obtain its coenzyme A entirely from the host cell during infection.
摘要
正常鸭红细胞和感染了罗氏疟原虫的红细胞都具备辅酶A生物合成所需的所有酶，而从宿主细胞中游离出来的寄生虫则没有。由于罗氏疟原虫的无红细胞培养需要外源性辅酶A，这种寄生虫在感染期间必定完全从宿主细胞获取其辅酶A。
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1
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J Biol Chem. 1951 Aug;191(2):515-21.
2
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J Exp Med. 1950 Oct 1;92(4):349-66. doi: 10.1084/jem.92.4.349.
3
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J Exp Med. 1961 Dec 1;114(6):1049-62. doi: 10.1084/jem.114.6.1049.
4
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J Biol Chem. 1953 Jul;203(1):47-54.
5
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