Förstl Hans
TU Munich, Klinikum rechts der Isar der TUM, Germany.
Curr Opin Psychiatry. 2005 Nov;18(6):615-20. doi: 10.1097/01.yco.0000185717.57117.08.
While we adhere to traditional misconceptions regarding the nature of age-associated neurodegenerative, and vascular and other brain changes, we will not re-design our research projects, and we will not reconsider and improve our pragmatic diagnostic and therapeutic approach.
This review focuses (1) on the continuum of cognitive deficits from mild cognitive impairment to manifest dementia, (2) on the spectrum of neurodegenerative, vascular and other cerebral co-morbidity, and (3) on some reversible examples of the rare outliers (limbic encephalitis, Hashimoto encephalopathy) not to be included in the common severity and cerebral co-morbidity spectrum of senile cognitive impairment.
We will only be more informed if we accept appropriate concepts and draw the right conclusions. Important new research has not yet filtered into the minds of dementia researchers specializing in 'normal ageing' or 'mild cognitive impairment', 'Alzheimer's disease' or 'dementia with Lewy bodies', tauopathies or synucleopathies, etc.
如果我们坚持关于年龄相关神经退行性病变、血管病变及其他脑部变化本质的传统错误观念，我们就不会重新设计研究项目，也不会重新审视和改进我们的实用诊断及治疗方法。
本综述聚焦于：（1）从轻度认知障碍到显性痴呆的认知缺陷连续体；（2）神经退行性病变、血管病变及其他脑部共病谱；（3）一些罕见的不属于老年认知障碍常见严重程度和脑部共病谱的可逆性病例（边缘性脑炎、桥本脑病）。
只有接受恰当的概念并得出正确结论，我们才能了解更多信息。重要的新研究尚未渗透到专注于“正常衰老”或“轻度认知障碍”、“阿尔茨海默病”或“路易体痴呆”、tau蛋白病或突触核蛋白病等的痴呆症研究人员的头脑中。
