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[青光眼的激光手术:准分子激光小梁切开术]

[Laser surgery for glaucoma: excimer-laser trabeculotomy].

作者信息

Pache M, Wilmsmeyer S, Funk J

机构信息

Universitäts-Augenklinik Freiburg, Freiburg.

出版信息

Klin Monbl Augenheilkd. 2006 Apr;223(4):303-7. doi: 10.1055/s-2005-858861.

Abstract

BACKGROUND

Excimer-laser trabeculotomy (ELT) is a new, minimally invasive surgical procedure for the treatment of open-angle glaucoma that can easily be combined with cataract surgery. We herein report our experience with ELT as a stand-alone procedure and ELT plus cataract surgery.

METHODS

A total of 135 patients with open-angle glaucoma (n = 128) or ocular hypertension (n = 7) (M : F = 49 : 86, mean age 69.7 +/- 1.2 years) were included in this study. Patients were divided into 2 groups: a) ELT as a stand-alone procedure (n = 75), b) combined cataract and ELT procedure (n = 60). Both groups were further divided into 2 subgroups: 1) Preoperative IOP > 22 mmHg, 2) Preoperative IOP < or = 22 mmHg. Kaplan-Meier survival curves were calculated. Success criterion was 20 % decrease of IOP and IOP < or = 21 mmHg and postoperative IOP-lowering medication < or = preoperative IOP-lowering medication. Follow-up time was 1 year.

RESULTS

Group a) ELT, 1) preoperative IOP > 22 mmHg, 2) preoperative IOP < or = 22 mmHg: Kaplan-Meier survival curves showed a success rate of 57 % in subgroup 1 and of 41 % in subgroup 2. Group b) Combined cataract and ELT procedure, 1) preoperative IOP > 22 mmHg, 2) Preoperative IOP < or = 22 mmHg: success rate was 91 % in subgroup 1 and 52 % in subgroup 2.

CONCLUSION

ELT is a promising IOP-lowering technique both as a stand-alone procedure and in combination with cataract surgery. It is especially suitable for patients with high preoperative IOP levels.

摘要

背景

准分子激光小梁切开术(ELT)是一种用于治疗开角型青光眼的新型微创手术,可轻松与白内障手术联合进行。我们在此报告我们将ELT作为单独手术以及ELT联合白内障手术的经验。

方法

本研究共纳入135例开角型青光眼患者(n = 128)或高眼压症患者(n = 7)(男:女 = 49:86,平均年龄69.7±1.2岁)。患者分为2组:a)ELT单独手术组(n = 75),b)白内障与ELT联合手术组(n = 60)。两组又进一步分为2个亚组:1)术前眼压>22 mmHg,2)术前眼压≤22 mmHg。计算Kaplan-Meier生存曲线。成功标准为眼压降低20%且眼压≤21 mmHg,以及术后降眼压药物用量≤术前降眼压药物用量。随访时间为1年。

结果

a组ELT,1)术前眼压>22 mmHg,2)术前眼压≤22 mmHg:Kaplan-Meier生存曲线显示,亚组1成功率为57%,亚组2为41%。b组白内障与ELT联合手术,1)术前眼压>22 mmHg,2)术前眼压≤22 mmHg:亚组1成功率为91%,亚组2为52%。

结论

ELT作为单独手术或与白内障手术联合应用时,都是一种有前景的降眼压技术。它特别适合术前眼压较高的患者。

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